Shanghai Keqin Wraps the Basement Membrane in Liposomes to Beat the Big-Molecule Problem

Original headline (CN): 上海克琴为基底膜功效护肤原料开发提供新思路！

Shanghai Keqin Technology has introduced BiocosMed-ECM, a basement-membrane liposome aimed at the dermal-epidermal junction — the roughly 0.1-micron band that anchors the epidermis to the dermis, supports structure and relays cell signals, and whose degradation shows as sagging, recurring sensitivity and poor penetration. The problem it addresses is blunt: basement-membrane proteins run to hundreds of kilodaltons and cannot cross the stratum corneum, so topical versions sit on the surface. Keqin's answer is a full-spectrum natural extract — collagens I, III, IV, VII and XVII plus laminin and nidogen — encapsulated in liposomes. The category is established. Shiseido began basement-membrane photoaging work in the 1990s and screened more than 20,000 ingredients; L'Oreal's Pro-Xylane acts partly through extracellular matrix and basement-membrane collagen expression. Domestically Proya started DEJ research in 2014 and uses type XVII recombinant collagen in its Source Power line; Shanghai Chengmu, parent of Zhiben, holds a DEJ-repair patent covering COL7A1, COL17A1 and laminin-5; Comfy built its collagen stick around recombinant type IV. Keqin's differentiation is delivery engineering, n

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